Papers should be complete and essentially final reports. The subject area of FEBS Letters is broad. Articles can be classified under the following categories: Bioenergetics; Biophysics, Cell fate determination (cell cycle, cell differentiation, cell death); Chemical Biology; Computation Biology (genomics, proteomics, bioinformatics); Cytoskeleton; Development; Ezymology; Evolution; Genome organization and stability; Glycobiology; Immunology; Membrane Biology (membrane trafficking, vesicles, organelles); Metabolism; Microbiology; Molecular basis of disease; Neuroscience; Plant Biology; Protein Chemistry; Protein Homeostasis; Redox Biology; Regulation of gene expression; RNA Biology; Signal Transduction; Structural Biology; Synthetic Biology; Systems Biology; and Virology. As a general policy, FEBS Letters does not consider preliminary or fragmentary observations, cloning and sequencing of cDNA or genes that have previously been reported for other species, conventionally achieved expression or crystallization of proteins, description of the effect of a drug or reagent without elucidation of a detailed molecular mechanism, correlative studies or negative observations. Moreover, methodological papers are considered for publication only when they are truly novel and significant, and interesting to a broad readership.